2024
36. Shannon C. Barbarek, Ritika Shah, Sharanya Paul, Gloria Alvarado, Keerthi Appala, Emma C. Henderson, Evan T. Strandquist, Antje Pokorny, Vineet K. Singh, Craig Gatto, Jan-Ulrik Dahl, Kelly M. Hines, Brian J. Wilkinson, “Lipidomics of homeoviscous adaptation to low temperatures in Staphylococcus aureus utilizing exogenous straight-chain unsaturated fatty acids over biosynthesized endogenous branched-chain fatty acids,” bioRxiv 2024.02.02.578686. [Preprint]
35. Andrew M. Larey, Thomas M. Spoerer, Kanupriya R. Daga, Maria G. Morfin, Hannah M. Hynds, Jana M. Carpenter, Kelly M. Hines, and Ross A. Marklein, “High throughput screening of mesenchymal stromal cell morphological response to inflammatory signals for bioreactor-based manufacturing of extracellular vesicles that modulate microglia,” Bioactive Materials, 2024, 37, 153-171.
34. Hannah M. Hynds and Kelly M. Hines#, “MOCCal: A Multi-Omic CCS Calibrator for Traveling Wave Ion Mobility Mass Spectrometry,” Analytical Chemistry, 2024, 96, 1185-1194. MOCCal Github
33. Jana M. Carpenter, Hannah M. Hynds, Kingsley Bimpeh, and Kelly M. Hines#, “HILIC-IM-MS for Simultaneous Lipid and Metabolite Profiling of Bacteria,” ACS Measurement Science Au, 2024, 4(1), 104-116. Invited contribution for 2023 Rising Stars in Measurement Science virtual special issue.
2023
32. Kingsley Bimpeh and Kelly M. Hines#, “A rapid single-phase extraction for polar staphylococcal lipids,” Analytical and Bioanalytical Chemistry, 2023, 415, 4591–4602. Invited contribution for Young Investigators in (Bio-)Analytical Chemistry 2023 Collection.
31. Christian D. Freeman, Jana M. Carpenter, Ramona Urbauer, Brian J. Wilkinson, Vineet K. Singh, and Kelly M. Hines#, “Defective pgsA contributes to increased membrane fluidity and cell wall thickening in S. aureus with high-level daptomycin resistance,” bioRxiv 2023.04.11.536441. [Preprint]
2022
30. Hideaki Tomita, Kelly M. Hines, Josi M. Herron, Amy Li, David W. Baggett, and Libin Xu, “7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in Smith-Lemli-Opitz syndrome,” eLife, 2022, 11:e67141.
29. Hannah M. Hynds and Kelly M. Hines#, “Ion Mobility Shift Reagents for Lipid Double Bonds based on Paternò-Büchi Photoderivatization with Halogenated Acetophenones,” Journal of the American Society for Mass Spectrometry, 2022, 33(10), 1982-1989.
28. Amy Li, Kelly M. Hines, Dylan H. Ross, James W. MacDonald, and Libin Xu, “Temporal Changes in the Brain Lipidome During Neurodevelopment of Smith-Lemli-Opitz Syndrome Mice,” Analyst, 2022, 147, 1611-1621.
27. Katherine E. Havranek, Judith M. R. Ballista, Kelly M. Hines# and Melinda A. Brindley#, “Untargeted Lipidomics of Vesicular Stomatitis Virus-Infected Cells and Viral Particles,” Viruses, 2022, 14(1), 3.
2021
26. Rutan Zhang, Ismael Barreras Beltran, Nathaniel K. Ashford, Kelsi Penewit, Adam Waalkes, Elizabeth A. Holmes, Kelly M. Hines, Stephen J. Salipante, Libin Xu, Brian J. Werth, “Synergy between beta-lactams and lipo-, glyco-, and lipoglycopeptides is independent of the seesaw effect in methicillin-resistant Staphylococcus aureus,” Frontiers in Molecular Biosciences, 2021, 8:688357.
25. Tianwei Shen, Kelly M. Hines, Nathaniel K. Ashford, Brian K. Werth, and Libin Xu, “Varied Contribution of Phospholipid Shedding from Membrane to Daptomycin Tolerance in Staphylococcus aureus,” Frontiers in Molecular Biosciences, 2021, 8:679949.
24. Christian Freeman, Hannah M. Hynds, Jana M. Carpenter, Keerthi Appala, Kingsley Bimpeh, Shannon Barbarek, Craig Gatto, Brian J. Wilkinson, and Kelly M. Hines#, “Revealing Fatty Acid Heterogeneity in Staphylococcal Lipids with Isotope Labeling and RPLC-IM-MS,” Journal of the American Society for Mass Spectrometry, 2021, DOI:10.1021/jasms.1c00092. Invited contribution for Emerging Investigators Special Focus Issue.
23. Marley Brimberry, Marina Ana Toma, Kelly M. Hines, William N. Lanzilotta, “HutW from Vibrio cholerae is an Anaerobic Heme-Degrading Enzyme with Unique Functional Properties,” Biochemistry, 2021, 60 (9), 699-710.
2020
22. Dylan H. Ross, Jang Ho Cho, Rutan Zhang, Kelly M. Hines, and Libin Xu, “LiPydomics: A Python Package for Comprehensive Prediction of Lipid Collision Cross Sections and Retention Times and Analysis of Ion Mobility-Mass Spectrometry-Based Lipidomics Data,” Analytical Chemistry, 2020, 92 (22), 14967–14975.
21. Brian J. Werth, Nathaniel K. Ashford, Kelsi Penewit, Adam Waalkes, Elizabeth A. Holmes, Dylan H. Ross, Tianwei Shen, Kelly M. Hines, Stephen J. Salipante, and Libin Xu, “Dalbavancin exposure in vitro selects for dalbavancin-non-susceptible and vancomycin-intermediate strains of methicillin-resistant Staphylococcus aureus,” Clinical Microbiology and Infection, 2020, DOI:10.1016/j.cmi.2020.08.025.
20. Kelly M. Hines, Gloria Alvarado, Xi Chen, Craig Gatto, Antje Pokorny, Francis Alonzo III, Brian J. Wilkinson, and Libin Xu, “Lipidomic and Ultrastructural Characterization of the Cell Envelope of Staphylococcus aureus Grown in the Presence of Human Serum,” mSphere, 2020, 5:e00339-20.
19. Keerthi Appala*, Kingsley Bimpeh*, Christian Freeman*, and Kelly M. Hines#, “Recent applications of mass spectrometry in bacterial lipidomics,” Analytical and Bioanalytical Chemistry, 2020, 412, 5935–5943. Invited contribution for Female Role Models in Analytical Chemistry Special Issue. *These authors contributed equally.
18. Kelly M. Hines, Tianwei Shen, Nathaniel K. Ashford, Adam Waalkes, Kelsi Penewit, Elizabeth A. Holmes, Kathryn McLean, Stephen J. Salipante, Brian J. Werth, Libin Xu, “Occurrence of cross-resistance and β-lactam seesaw effect in glycopeptide-, lipopeptide- and lipoglycopeptide-resistant MRSA correlates with membrane phosphatidylglycerol levels,” Journal of Antimicrobial Chemotherapy, 2020, dkz562.
Publications Prior to UGA
Journal Articles
17. Aurore Fleurie, Abdelrahim Zoued, Laura Alvarez, Kelly M. Hines, Felipe Cava, Libin Xu, Brigid M. Davis, Matthew K. Waldor, “A Vibrio cholerae BolA-like protein is required for proper cell shape and cell envelope integrity,” mBio, 2019, 10, e00790-19.
16. Josi M. Herron, Kelly M. Hines, Hideaki Tomita, Ryan P. Seguin, Julia Yue Cui, Libin Xu, “Multiomics investigation reveals benzalkonium chloride disinfectants alter sterol and lipid homeostasis in the mouse neonatal brain,” Toxicological Sciences, 2019, 171, 32-45.
15. Kelly M. Hines and Libin Xu, “Lipidomic consequences of phospholipid synthesis defects in Escherichia coli revealed by HILIC-ion mobility-mass spectrometry,” Chemistry and Physics of Lipids, 2019, 219, 15-22.
14. Elijah J. Weber, Kevin A. Lidberg, Lu Wang, Theo K. Bammler, James W. MacDonald, Mavis J. Li, Michelle Redhair, William M. Atkins, Cecilia Tran, Kelly M. Hines, Josi Herron, Libin Xu, Maria Beatriz Monteiro, Susanne Ramm, Vishal Vaidya, Martti Vaara, Timo Vaara, Jonathan Himmelfarb, Edward J. Kelly, “Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity,” JCI Insight, 2018, 3, e123673.
13. Josi Herron, Kelly M. Hines, and Libin Xu, “Assessment of altered cholesterol homeostasis by xenobiotics using ultra-high performance liquid chromatography-tandem mass spectrometry,” Current Protocols in Toxicology, 2018, 78, e65.
12. David R. Raleigh, Navdar Sever, Pervinder K. Choksi, Monika Abedin Sigg, Kelly M. Hines, Bonne M. Thompson, Daniel Elnatan, Priyadarshini Jaishankar, Paola Bisignano, Francesc R. Garcia-Gonzalo, Alexis Leigh Krup, Markus Eberl, Eamon F. X. Byrne, Christian Siebold, Sunny Y. Wong, Adam R. Renslo, Michael Grabe, Jeffrey G. McDonald, Libin Xu, Philip A. Beachy, Jeremy F. Reiter, “Cilia-associated oxysterols activate Smoothened,” Molecular Cell, 2018, 72 (2), 316-327.
11. Steven J. Fliesler, Neal S. Peachy, Josi Herron, Kelly M. Hines, Nadav I. Weinstock, Sriganesh Ramachandra Rao, Libin Xu, “Prevention of Retinal Degeneration in a Rat Model of Smith-Lemli-Opitz Syndrome,” Scientific Reports, 2018, 8 (1), 1286. Author Correction: 2018, 8 (1), 4289.
10. Kelly M. Hines, Adam Waalkes, Kelsi Penewit, Elizabeth A. Holmes, Stephen J. Salipante, Brian J. Werth, Libin Xu, “Characterization of the Mechanisms of Daptomycin Resistance among Gram-Positive Bacterial Pathogens by Multidimensional Lipidomics,” mSphere, 2017, 2 (6), e00492-17.
9. Kelly M. Hines, Dylan H. Ross, Kimberly L. Davidson, Matthew F. Bush, Libin Xu, “Large-Scale Structural Characterization of Drug and Drug-like Compounds by High-Throughput Ion Mobility-Mass Spectrometry,” Analytical Chemistry, 2017, 89 (17), 9023-9030.
8. Kelly M. Hines, Josi Herron, Libin Xu, “Assessment of altered lipid homeostasis by HILIC-ion mobility-mass spectrometry-based lipidomics,” Journal of Lipid Research, 2017, 58, 809-819.
7. Carrie J. Finno, Matthew H. Bordbari, Stephanie J. Valberg, David Lee, Josi Herron, Kelly Hines, Tamer Monsour, Erica Scott, Danika L. Bannasch, James Mickelson, Libin Xu, “Transcriptome profiling of equine vitamin E deficient neuroaxonal dystrophy identifies upregulation of liver X receptor target genes,” Free Radical Biology and Medicine, 2016, 101, 261-271.
6. Kelly M. Hines, Jody C. May, John A. McLean, Libin Xu, “Evaluation of Collision Cross Section Calibrants for Structural Analysis of Lipids by Traveling Wave Ion Mobility-Mass Spectrometry,” Analytical Chemistry, 2016, 88 (14), 7329-7336.
5. Kelly M. Hines, G. Charles Ford, Katherine Klaus, Brian Irving, Beverly Ford, Kenneth Johnson, Ian Lanza, K. Sreekumaran Nair, “Application of high-resolution mass spectrometry to measure low abundance isotope enrichment in individual muscle proteins,” Analytical and Bioanalytical Chemistry, 2015, 407 (14), 4045-4052.
4. Kelly M. Hines, Billy R. Ballard, Dana M. Marshall and John A. McLean, “Structural mass spectrometry of tissue extracts to distinguish cancerous and non-cancerous breast diseases,” Molecular BioSystems, 2014, 10 (11), 2827-3032.
3. J. Corey Evans, Kelly M. Hines, Jay G. Forsythe, Begum Erdogan, Mingjian Shi, Salisha Hill, Kristie L. Rose, John A. McLean and Donna J. Webb, “Phosphorylation of Serine 106 in Asef2 Regulates Cell Migration and Adhesion Turnover,” Journal of Proteome Research, 2014, 13 (7), 3303-3313.
2. Kelly M. Hines, Samir Ashfaq, Jeffrey M. Davidson, Susan R. Opalenik, John P. Wikswo and John A. McLean, “Biomolecular Signatures of Diabetic Wound Healing by Structural Mass Spectrometry,” Analytical Chemistry, 2013, 85 (7), 3651-3659.
1. Alexander P. Lamers, Mary E. Keithly, Kwangho Kim, Paul D. Cook, Donald F. Stec, Kelly M. Hines, Gary A. Sulikowski, and Richard N. Armstrong, “Synthesis of Bacillithiol and the Catalytic Selectivity of FosB-Type Fosfomycin Resistance Proteins,” Organic Letters, 2012, 14 (20), 5207-5209.
Invited Book Chapters
3. Amy Li, Kelly M. Hines, Libin Xu, “Lipidomics by HILIC-Ion Mobility-Mass Spectrometry,” Invited chapter for inclusion in “Ion Mobility Mass Spectrometry – Methods and Protocols,” Giuseppe Paglia and Giuseppe Astarita, Eds. Springer. 2019.
2. Sarah M. Stow, Nichole M. Lareau, Kelly M. Hines, C. Ruth McNees, Cody R. Goodwin, Brian O. Bachmann, and John A. McLean, “Structural separations for natural product characterization by ion mobility-mass spectrometry: Fundamental theory to emerging applications,” Invited chapter for inclusion in “Natural Products Analysis: Instrumentation, Methods and Applications,” Vladimir Havlicek and Jaroslav Spizek, Eds. John Wiley & Sons, Inc. 2013.
1. Kelly M. Hines, Jeffrey R. Enders, and John A. McLean, “Multidimensional Separations by Ion Mobility-Mass Spectrometry,” Invited chapter for inclusion in “Encyclopedia of Analytical Chemistry (online),” Robert Myers and David Muddiman, Eds. John Wiley & Sons, Ltd. 2012.